Skin scar is unique to humans, the major significant negative outcome sustained after thermal injuries, traumatic injuries, and surgical procedures. Hypertrophic scar in human skin is investigated using non-linear spectral imaging microscopy. The high contrast images and spectroscopic intensities of collagen and elastic fibers extracted from the spectral imaging of normal skin tissue, and the normal skin near and far away from the hypertrophic scar tissues in a 10-year-old patient case are obtained. The results show that there are apparent differences in the morphological structure and spectral characteristics of collagen and elastic fibers when comparing the normal skin with the hypertrophic scar tissue. These differences can be good indicators to differentiate the normal skin and hypertrophic scar tissue and demonstrate that non-linear spectral imaging microscopy has potential to noninvasively investigate the pathophysiology of human hypertrophic scar.

Employing nonlinear spectral imaging technique based on two-photon-excited fluorescence and second-harmonic generation (SHG) of biological tissue, we combine the image-guided spectral analysis method and multi-channel subsequent detection imaging to map and visualize the intrinsic species in a native rabbit aortic wall. A series of recorded nonlinear spectral images excited by a broad range of laser wavelengths (730-910 nm) are used to identify five components in the native rabbit aortic wall, including nicotinamide adenine dinucleotide (NADH), elastic fiber, flavin, porphyrin derivatives, and collagen. Integrating multi-channel subsequent detection imaging technique, the high-resolution, high contrast images of collagen and elastic fiber in the aortic wall are obtained. Our results demonstrate that this method can yield complementary biochemical and morphological information about aortic tissues, which have the potential to determine the tissue pathology associated with mechanical properties of aortic wall and to evaluate the pharmacodynamical studies of vessels.

An all-fiber Yb^(3+)-doped double-clad fiber laser using FBGs as cavity mirrors is investigated in this paper. Continuous-wave (CW) output power of 1.18 W with defined wavelength at 1.06 μm and narrow line-width of less than 0.1 nm is obtained. The slope efficiency and the maximum optical-to-optical efficiency of laser output are 68% and 51%, respectively, with respect to absorbed pump power.

本文从时域特性出发,分析了锁模Ar+激光器中噪声的来源,假设表征光脉冲强度涨落的随机函数为A(t)=Aoexp[-i(Ωt+(?)_t)],得到描述光强涨落的噪声谱为罗仑兹线形,这与实验结果是一致的.

对通过光纤的激光时间相干性及其变化规律进行了实验研究,并提出一种确定时间相干函数的实验方法.

较全面地报道了与位相各向异性有关的内腔He-Ne激光器振荡模偏振特性实验资料,并借助于Lamb理论对实验现象作了理论解释。

用光学混频技术研究了平凹腔结构气体激光器的模差拍。实验中应用了不同腔长的He-Ne(6328)和Ar+激光器。根据腔长的随机变化、介质色散特性和模竞争效应解释了低频拍和连续噪声谱。